selank log, 8 weeks in, trying to keep it honest

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seqfocusAug 10, 2025 at 8:52 PM

ok so i promised myself id actually post updates on this instead of just collecting data in a tab nobody sees. here goes. **starting stats:** starting weight: 214 lbs. current: 197 lbs. dose schedule has been 250mcg intranasal BID, bumped to 500mcg BID around week 5. vendor COA came back 98.1% HPLC which is fine, not spectacular. **weeks 1-2** honestly not much. maybe a slight edge on focus but i was also sleeping better that week so... placebo is always on the table. zero sides. food noise unchanged, which is relevant because i wasnt running this for appetite, i was running it for the anxiolytic + cognitive angle. logged my subjective focus at about a 5.5/10 baseline going in. **weeks 3-4** this is where it got interesting, or i convinced myself it did. focus scores in my sheet bumped to 6.8 average over the two weeks. less rumination during work blocks, which is the thing i actually care about. sleep latency felt shorter but i dont have a tracker so thats fully vibes. no GI weirdness, no headaches. i was bracing for some fatigue bump that people mention and it just... didnt happen for me. weight is dropping but im also eating less, not because of Selank specifically but because i got my act together on food around the same time. so i cant attribute that. would be dishonest to. **weeks 5-6** bumped the dose. this is where i noticed the most consistent effect on what i can only call background anxiety. the low-level hum that usually lives under everything just... quieted some. still not claiming cause and effect, could be seasonal, could be placebo operating at full power. but it showed up in the spreadsheet as my best focus weeks by a margin. one annoying thing: nasal irritation around day 4-5 of each week. not bad, just noticeable. switched nostrils more deliberately and it helped. **weeks 7-8** seems like it's leveling off a bit. focus scores back to 6.2ish. the anxiety-quiet effect is still there but feels more like a floor than a ceiling now. might be adaptation. might have just been a good 8 weeks in general. this is the slippery part of nootropic research that drives me a little nuts, you cant blind yourself. weight is at 197, down 17 lbs, but again that's food and movement, not Selank. i'd feel weird attributing that. anyway, for those who've run longer protocols (12+ weeks), did the cognitive effects stabilize for you or did they fade back to baseline? and did you cycle, or just keep going?

5 Replies

lena_999 months ago

the nasal irritation thing, YES. i had that in my first few weeks and panicked that i was doing something wrong. turned out i was just being sloppy about which nostril and not letting it clear between administrations. alternating properly basically fixed it for me. also really appreciate you being upfront that the weight drop is food + movement and not the peptide. that kind of honesty is why i keep reading logs here instead of the usual stuff where everything gets attributed to whatever the person is running that month lol how are you logging the focus scores, like what's the actual scale or criteria? im curious whether yours is anchored to anything specific or more gestalt.

domresearch9 months ago

appreciate the honest write-up. the 'slippery' thing you mention at the end is real and i dont think enough people in these logs acknowledge it. i ran a 10 week Selank protocol about a year back and had a similar leveling experience around week 7-8. in fairness to the compound though, i was also going through a stressful stretch at work so my baseline was a moving target the whole time. hard to know what was what. one thing i'll flag: the vendor i used at the time had inconsistent stock on the intranasal formulation and i had a gap around week 6 where i was waiting on a restock. in fairness to them they did ship fast once it came back but that gap might have messed with any consistent signal i could have reported. still a bit annoyed about it honestly. anyway, curious if you cycled off at all between weeks or ran it straight through.

nzt20489 months ago

98.1% HPLC is acceptable depending on the column and what theyre reporting as the main peak. what method did the vendor use, reverse phase C18 or something else? i ask because ive seen vendors report that number on a short gradient run that doesnt fully resolve the adjacent peaks, so the "98.1" is flattering. ran a batch of Selank myself last quarter (Phenomenex Luna C18, 15-min gradient, UV at 220nm). came back 97.4%, which i was happy with given the source. the peptide degrades fast in solution if pH isnt controlled so reconstitution water matters more than people think here. not saying your batch is bad. just that a number without methodology is half a number.

bpcwatcher8 months ago

logging this kind of thing in a spreadsheet is exactly right imo. i do the same for BPC protocols and the number of times ive caught myself narratively inflating an effect that the sheet just doesnt support... embarrassing. your week 5-6 description of 'background anxiety quieting', on my own logs i've called that a 3/10 to 1/10 shift in baseline noise. not dramatic but consistent. the nights where i marked it as placebo-suspect were usually nights where something else had gone well that day. hard to untangle. the adaptation thing is real. i see it in peptide logs too. week 8-10 you hit a kind of ceiling and then you have to decide whether to cycle or accept that this is just the new floor. open question whether the floor is worth maintaining or whether you need the washout to reset sensitivity.

caleb19928 months ago

the sleep latency comment caught my eye. i dont have data on Selank specifically but on my IPA/CJC logs (90 min pre-bed, consistent timing) the Oura ring picked up a meaningful deep sleep increase around week 3-4 that i wasnt expecting. couldnt tell you if it was peptide, the routine, or the fact that i stopped looking at my phone after 9pm that same week, which is exactly your placebo problem in wearable form. if you ever get a tracker even just for a few weeks mid-protocol it's worth it just to see if your subjective 'sleep felt shorter' lines up with the deep sleep graph. sometimes it does. sometimes it really doesnt and that's its own kind of information. vivid dreams picked up for me around week 5 btw, no idea if thats relevant to anything but figured i'd mention it since you're tracking subjective stuff.

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